Gruppo Viola

CENTRO DI RICERCA
ISTITUTO CLINICO HUMANITAS, ROZzANO, mILANO, iTALIA
Group Leader
Dr Antonella Viola
antonella.viola@unimi.it
Componenti
 
 
Debora Avella
Elisa Cerutti
Javier Cibella
Rita Lucia Contento
Francesca Dionisio
Marinos Kallikourdis
Cristina Mazzon
Sara Morlacchi
Adelaida Sarukhan
Cristiana Soldani
Anna Elisa Trovato
Lucia Zanotti
Mary Wang
 
Interessi Scientifici
 
 
modulazione della risposta immune adattativa in condizioni fisiopatologiche:
- Signalling del calcio nell’attivazione dei linfociti T in vitro e nel microambiente linfonodale
- Ruolo dell'agrina nell'attivazione e migrazione dei linfociti T
- Meccanismi di immunosoppressione operati dalle cellule T regolatrici
- Caratterizzazione della capacità immunomodulatorie di Cellule Staminali Mesenchimali
- Il ruolo del recettore chemochinico CXCR4 nella malattia di WHIM
- I linfociti infiltranti i tumori
Attività Clinico/Assistenziale
 
/
Expertise
 
Microscopia
Isto-patologia e immunoistochimica
Modelli in vivo di infiammazione antigene-specifica
Saggi di attivazione in vitro di cellule T (umane e murine)
Pubblicazioni caratterizzanti
 
 
V. Bronte, T. Kasic, G. Gri, K. Gallana, G. Borsellino, I. Marigo, L. Battistini, M. Iafrate, T. Prayer-Galetti, F. Pagano and A. Viola. 2005. Boosting anti-tumor responses of T lymphocytes infiltrating human prostate cancers. The Journal of Experimental Medicine, 201:1257-68.
B. Molon, G. Gri, M. Bettella, C. Goumez-Mouton, A. Lanzavechia, C. Martinez-A, S. Manes and A. Viola. 2005. T cell costimulation by chemokine receptors. Nature Immunology, 6:465-71 .
R. Tavano, R.L. Contento, S.J. Baranda, M. Soligo, L. Tuosto, S. Manes and A. Viola. 2006. CD28 interaction with filamin-A controls lipid raft accumulation at the T cell immunological synapse. Nature Cell Biology, 8:1270-1276
R.L. Contento, B. Molon, C. Boularan, T. Pozzan, S. Manes, S. Marullo and A. Viola. 2008. CXCR4-CCR5: a couple modulating T-cell functions. Proceedings of the National Academy of Science, Jul 22;105(29):10101-6. Epub 2008 Jul 15.
Dal Secco V, Soldani C, Debrat C, Asperti-Boursin F, Donnadieu E, Viola A, Sarukhan A. 2009. Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes. PLoS One. Nov 6;4(11):e7696.
Strumentazioni disponibili
 
 
Flow cytometers FACSCanto and FACSAria; Perkin Elmer 7990HT Real-Time PCR system; Video Imaging Systems CellR IX81 (Olympus); Confocal Microscope FV1000 (Olympus), furnished with cage incubator (CO2 and temperature control) and micromanipulator (specific applications: xz stacks, FRET, photo-bleaching); Confocal Microscope FV1000 (Olympus), furnished with cage incubator (CO2 and temperature control) and the EVA modulus for TIRF; Luminescent fluorimeter; Multiphoton microscope system Trim Scope II (LaVision Biotech) with single and multi beam functionality equipped with an xyz-stage for intravital microscopy and designed to allow running of complex protocols including FLIM, FRAP, Uncaging and Photo Activation.
 

 
 
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